I think it was some sort of bacterial infection, whether it be Flex or something else.
I had an oto who had the same thing,
and the white spot was a "scab".
When I started treating with M2,
the scab came off, and I saw the GIANT hole in her head.

The M2 healed the wound, and the skin grew into
the hole, and she survived.

If you ever see something like this again, don't hesitate to treat with a 5 day course of M2..
I'm sorry.
LOVE JBOT

PS. I used to have a frog named Piggy....RIP...